mycoplasma contaminants can be considered important not only for their roles as pathogens but also they may indicate that insufficient care has been taken during vaccine manufacture or quality control. the purpose of this study was to test the poliomyelitis vaccines for mycoplasma by culture and polymerase chain reaction (pcr) methods. during 2008 to 2009, a total of 47 lots of oral poliomyelit...

Poliomyelitis is an exclusively human disease that mainly affects children. Clinical features of poliomyelitis can be varied, from mild illness to the most severe paralysis, and factor why has different performances in individuals been proved strongly correlated with membrane protein CD155. The nervous system shows a special protecting phenomenon against invasion poliovirus, mechanism not very ...

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The Epidemiology of poliomgelitis has been investigated in our country Pasteur Institute; the incidence of Poliomgelitis, after the age of 4 years i's rare, in Iran.  Passive antibody of maternal origin do not interfere with production of active antibody after immunization.  Inactivated Polio Vaccine (salk) has been effective in reducing the incidence of poliomge­litis by approximately 90 per ...

Poliomyelitis associated with live strain vaccine is defined as the paralytic form of the acute anterior poliomyelitis related to the vaccine strain. Since these strains behave similarly to the wild-type virus, we can differentiate, epidemiologically, two types of vaccine-associated poliomyelitis: cases in which the patient was vaccinated and cases in which the patient had had contact with vacc...

BACKGROUND The international spread of wild poliomyelitis outbreaks continues to threaten eradication of poliomyelitis and in 2014 a public health emergency of international concern was declared. Here we describe a risk scoring system that has been used to assess country-level risks of wild poliomyelitis outbreaks, to inform prioritisation of mass vaccination planning, and describe the change i...

In 1988 the World Health Assembly set the goal of global poliomyelitis eradication by the year 2000. Substantial progress has been made, and 143 countries reported no poliomyelitis cases associated with the wild virus in 1993. This article reviews the immunological considerations relevant to interrupting the transmission of wild polioviruses with vaccines. Although serum immunity prevents polio...

When, in 1956, inactivated poliomyelitis (Salk) vaccine became available for routine immunization in England and Wales the Ministry of Health set up a scheme of poliomyelitis surveillance. The objects were to provide a means of rapid detection pf possible outbreaks of vaccine-induced poliomyelitis, such as occurred in the United States owing to the presence of incompletely inactivated virus in ...

In 1958 Poliomyelitis Institute in Moscow and Institute of Experimental Medicine in St. Petersburg received from A. Sabin the attenuated strains of poliomyelitis virus. The characteristics of the strains were thoroughly studied by A. A. Smorodintsev and coworkers. They found that the virulence of the strains fluctuated slightly in 10 consecutive passages through the intestine of the non-immune ...